PhD Robin Blom

To evaluate a treatment that aims to reduce the deteriorating effect of cellular shear stress in a cartilage lesion and thereby prevent the vicious circle of trauma-induced ankle osteoarthritis. Here we propose the intra-articular injection of the elastic hydrogel ‘RegenoGel, a combination of hyaluronic acid and fibrinogen’.

Study objectives:

  • to establish a reproducible ex vivo caprine model of initiating, trauma-induced ankle osteoarthritis
  • to evaluate the mechano-biological efficacy of an elastic hydrogel to prevent trauma-induced degeneration of the articular cartilage
  • to evaluate the safety and efficacy of intra-articular administration of RegenoGel to patients suffering an ankle trauma.