PhD Emilie Donders

Despite ongoing advances in the treatment and increasing biological knowledge fracture-healing, an estimated 5% to 10% of fractures do not heal properly and go on to nonunion. The purpose of this thesis is to obtain detailed understanding of normal and disrupted fracture healing, to constitute a foundation for new approaches to stimulate bone healing and treat non-healing of a fracture. To attain this goal, the cell signaling pathways (Wnt) will be investigated using human callus and nonunion tissues. Secondary, to clinical studies involving diagnostics and operative treatment of nonunions will be performed.