To excel in our multidisciplinary sports medicine care, the athletes presenting their clinical problems serve to focus our research lines covering improvements in the entire backbone of the clinical workflow (red blocks). Those improvements encompass two major components: fundamental research in biology and biomechanics of tissues (right arm) and innovation (middle arm) by applied biomedical and technical research and development including clinical trials and formation of guidelines to implement the new insights and make patients benefit. This view on research has led to several innovative developments for significantly improved diagnosis, interventions and rehabilitation protocols having a true impact on improving sports medicine healthcare. Examples are MRI DTI imaging, Lift, drill, fill and fix (LDFF) arthroscopic technique and the surgical steerable punch. In the near future, we elaborate our research to include preventive strategies by focussing on risk profiling induced by big data sets coming from demographics, questionnaires, imaging, and computer modelling and to include improved rehabilitation by focussing on the implementation of eHealth and wearables technology in combination with our multidisciplinary expertise (blocks with blue text).